The Knowledge Base document is a core document for both Cranium and Synapse. Knowledge Base documents store chemical structures, physical property values, mixture compositions, estimation techniques, structural groups, elements and references.

• Cranium uses these data to estimate the properties of new chemicals, evaluate estimation techniques, compile physical property values, regress equations and graphically display property values.
• Synapse uses a Knowledge Base document as the source of data and estimation techniques for the design and selection of chemicals and mixtures.

A Knowledge base document contains seven chapters. Each of these chapters can be accessed by clicking on its corresponding tab in the document's Tab Pane.

Chapter	Description
Summary Chapter	manages title, descriptions and other information about the Knowledge Base document
Chemicals Chapter	manages identification, structure and physical properties of pure chemicals
Mixtures Chapter	manages composition and physical properties of mixtures of two or more chemicals
Techniques Chapter	manages model code, group contributions and parameters of estimation techniques used to predict physical property values
Groups Chapter	manages the molecular structure of groups used in estimation techniques, chemical designs and constraints
Elements Chapter	manages the atomic elements used to construct groups
References Chapter	manages the details of references used through the document

Topic	Description
Getting Started using Synapse	provides a quick tour of Synapse's capabilities including examples of chemical product design.
Getting Started using Cranium	provides a quick tour of Cranium's capabilities including a discussion of structure editing.
Estimating Chemical Properties	a short video demonstrating how to estimate the physical properties of chemicals using either Synapse or Cranium.
Estimating Mixture Properties	a short video demonstrating how to estimate the physical properties of mixtures using either Synapse or Cranium.